A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3
Abstract TL1A (TNFSF15) is a TNF superfamily ligand which can bind the TNFRSF member death receptor 3 (DR3) on T cells borstlist självhäftande and the soluble decoy receptor DcR3.Engagement of DR3 on CD4+ or CD8+ effector T cells by TL1A induces downstream signaling, leading to proliferation and an increase in secretion of inflammatory cytokines.